Edinson Cavani will remain with Manchester United over the international break after his call-up to the Uruguay squad was cancelled.
Premier League clubs had unanimously decided not to release players for World Cup qualifying and friendly matches in red-list countries.
Cavani was set to miss United games as Fifa extended the international windows by two days in South America.
He would also have had to quarantine for 10 days on his return to the UK.
Instead of joining up with his country for three World Cup qualifiers against Peru, Bolivia and Ecuador, Cavani will stay in the UK.
The Uruguayan Football Association said in a statement it had “decided to cancel the call for footballer Edinson Cavani”.